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Related Experiment Video

Updated: Jul 3, 2025

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

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Published on: October 27, 2023

Menopause-Associated Changes in Mandibular Bone Microarchitecture Are Site-Specific.

Michael Levit¹, Taylor Finn¹, Sanam Sachadava¹

¹Division of Orthodontics, Columbia University College of Dental Medicine, New York, NY.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons

|February 10, 2024

Summary

This summary is machine-generated.

Menopause significantly impacts mandibular condylar bone, increasing trabecular separation and reducing bone density. However, basal bone in the mandible remains largely unaffected by menopausal status.

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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

Area of Science:

Oral and Maxillofacial Surgery
Bone Biology
Menopause Research

Background:

Conflicting reports exist regarding estrogen's effect on mandibular bone microarchitecture.
The impact of menopause on different mandibular regions remains unclear, affecting treatment planning.

Purpose of the Study:

To evaluate and compare trabecular and cortical bone microstructure in the mandibular condyle and basal bone.
To assess differences between premenopausal and postmenopausal women.

Main Methods:

Cross-sectional cohort study at Columbia University Irving Medical Center.
Cone-beam computed tomography (CBCT) used for mandibular condyle and basal bone analysis.
Quantitative microstructure analysis of bone parameters including bone volume fraction, thickness, number, and separation.

Main Results:

Postmenopausal women exhibited significantly greater condylar trabecular separation and lower trabecular number compared to premenopausal women.
No significant differences in basal bone microarchitectural parameters were observed between menopausal groups.
Significant differences in age and estrogen levels were noted between premenopausal and postmenopausal groups.

Conclusions:

Menopause is linked to mandibular condylar trabecular bone loss.
Mandibular basal bone shows minimal changes related to menopausal status.
Findings have implications for treatment planning in aging populations, particularly concerning mandibular bone health.