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Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves

Yanju Huang1, Liwen Wu1, Yueshan Zhao1

  • 1State Key Laboratory of Animal Biotech Breeding, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Cell Reports
|February 11, 2024
PubMed

Insights

Interleukin-17B (IL-17B) from Schwann cells drives macrophage recruitment for nerve repair. Blocking IL-17B impairs myelin clearance and axon regeneration, offering targets for demyelinating diseases.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Macrophage recruitment is crucial for nerve repair following injury.
  • The precise mechanisms governing macrophage recruitment remain incompletely understood.
  • Wallerian degeneration involves myelin debris clearance and nerve regeneration.

Purpose of the Study:

  • To elucidate the molecular mechanisms regulating macrophage recruitment after peripheral nerve injury.
  • To identify key signaling pathways involved in Schwann cell-mediated nerve repair.
  • To investigate the role of IL-17B in macrophage infiltration and myelin clearance.

Main Methods:

  • Comparative analysis of wild-type, Mlkl-/-, and Sarm1-/- mice after peripheral nerve injury.
  • Assessment of macrophage infiltration, myelin debris clearance, and axon regeneration.
  • Investigation of the IL-17B signaling pathway in Schwann cells and injured nerves.

Main Results:

  • Interleukin-17B (IL-17B) was identified as a critical regulator of macrophage recruitment.
  • Schwann cell-secreted IL-17B acts via IL-17 receptor B in an autocrine manner.
  • Deletion of IL-17B, globally or in Schwann cells, reduced macrophage infiltration, myelin clearance, and axon regeneration.
  • The IL-17B signaling pathway was found to be defective in injured central nerves.

Conclusions:

  • Schwann cell autocrine IL-17B signaling plays a vital role in Wallerian degeneration.
  • IL-17B is a key mediator of macrophage recruitment essential for nerve repair.
  • Targeting the IL-17B pathway may accelerate myelin clearance and benefit demyelinating diseases.
Keywords:
CP: ImmunologyCP: NeuroscienceIL-17Schwann cellmacrophagenerve injurynerve regeneration

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