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Association of LDL-C/HDL-C ratio with coronary heart disease: A meta-analysis
Siqi Hu1, Hua Fan2, Shenghui Zhang1
1Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Institute of Cardiovascular Diseases, Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, 310015, China; Hangzhou Lin'an Fourth People's Hospital, Hangzhou, 311321, China.
Insights
The LDL-C to HDL-C ratio (LHR) is higher in individuals with coronary heart disease (CHD). This finding suggests LHR may be a useful indicator for detecting CHD risk.
Area of Science:
- Cardiology
- Biochemistry
- Public Health
Background:
- Coronary heart disease (CHD) is a leading cause of mortality globally.
- Dyslipidemia, characterized by abnormal blood lipid levels, is a key factor in coronary atherosclerosis progression.
- While individual lipid measures like LDL-C and HDL-C are linked to CHD, the significance of their ratio (LHR) remains under investigation.
Purpose of the Study:
- To comprehensively investigate the association between the LDL-C to HDL-C ratio (LHR) and coronary heart disease (CHD).
Main Methods:
- A systematic meta-analysis was conducted, searching major databases (PubMed, Embase, Web of Science, CNKI) up to June 15, 2023.
- Twelve relevant studies involving 5544 participants (3009 with CHD) were included.
- Data were pooled using a random-effects model to calculate the mean difference (MD) and 95% confidence intervals (CI).
Main Results:
- The meta-analysis revealed a significantly higher LHR in patients with CHD compared to those without CHD.
- The mean difference in LHR between the CHD and control groups was 0.65 (95% CI: 0.50-0.80).
Conclusions:
- The LDL-C to HDL-C ratio (LHR) is positively correlated with coronary heart disease (CHD).
- LHR may serve as a valuable and potential biomarker for identifying individuals at risk of CHD.
Background:
Coronary heart disease (CHD) is a common heart disease and a leading cause of death in developed countries and some developing countries such as China. It is recognized as a multifactorial disease, with dyslipidemia being closely associated with the progression of coronary atherosclerosis. Numerous studies have confirmed the relationship between a single indicator of low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C) and CHD. However, the association between LDL-C to HDL-C ratio (LHR) and CHD remains unclear. This study aimed to comprehensively explore the association between LHR and CHD.
Methods:
This meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses. PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases were comprehensively searched up to June 15, 2023, to find the studies that indicated the connection between LHR and CHD. A total of 12 published studies were selected. The random-effects model was used to pool the data and mean difference (MD), and the 95% confidence intervals (CI) were taken as the overall outcome. No language restrictions existed in the study selection. The Review Manager 5.4 and Stata 12 were used to analyze the data.
Results:
Twelve high-quality clinical studies involving 5544 participants, including 3009 patients with CHD, were enrolled in the meta-analysis. The findings revealed that the LHR was higher by 0.65 in patients with CHD than in those without CHD (MD, 0.65; 95% CI, 0.50-0.80).
Conclusion:
The LHR was found to be positively correlated with CHD, suggesting that it may serve as a potential indicator of CHD.
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