Related Experiment Video
Updated: May 5, 2026
10:32
Transvaginal Mesh Insertion in the Ovine Model
Published on: July 27, 2017
16.0K
A nine-month repeat-dose intravaginal ring (Ovaprene) irritation study in sheep
Sarah Davis1, Kelsey Parthun1, David R Friend2
1Surgery and Efficacy, Charles River Laboratories, Mattawan, MI, USA.
Contraception
|February 11, 2024
Summary
The investigational hormone-free contraceptive Ovaprene showed good tolerability in a nine-month sheep study. Histopathology and iron levels were comparable to controls, supporting further trials for this novel monthly ring.
Area of Science:
- Reproductive Health
- Contraception
- Toxicology
Background:
- Ovaprene is an investigational, intravaginal, hormone-free monthly ring contraceptive.
- Designed for women of reproductive age, it is worn for multiple weeks per menstrual cycle.
Purpose of the Study:
- To evaluate the safety and tolerability of Ovaprene.
- Assessed via a nine-month repeat-dose study in female sheep.
Main Methods:
- Histopathological examination of the female reproductive tract.
- Analysis of vaginal fluids for released iron.
- Measurement of serum iron levels.
- Assessment of iron content in removed Ovaprene rings.
Main Results:
- No macroscopic clinical findings were observed.
- Minimal to mild inflammatory cell infiltration in the vagina, similar to sham controls.
- Ovaprene ring treatment did not adversely affect the female reproductive tract.
- Serum iron levels remained comparable between Ovaprene and sham groups.
- Average release of ferrous gluconate was 175 mg over 29 days.
Conclusions:
- Ovaprene devices were well-tolerated in female sheep during the study period.
- The safety profile supports progression to chronic contraceptive efficacy studies in women.
