Unveiling combined ecotoxicity: Interactions and impacts of engineered nanoparticles and PPCPs

Emerging contaminants such as engineered nanoparticles (ENPs), pharmaceuticals and personal care products (PPCPs) are of great concern because of their wide distribution and incomplete removal in conventional wastewater and soil treatment processes. The production and usage of ENPs and PPCPs inevitably result in their coexistence in different environmental media, thus posing various risks to organisms in aquatic and terrestrial ecosystems. However, the existing literature on the physicochemical interactions between ENPs and PPCPs and their effects on organisms is rather limited. Therefore, this paper summarized the ecotoxicity of combined ENPs and PPCPs by discussing: (1) the interactions between ENPs and PPCPs, including processes such as aggregation, adsorption, transformation, and desorption, considering the influence of environmental factors like pH, ionic strength, dissolved organic matter, and temperature; (2) the effects of these interactions on bioaccumulation, bioavailability and biotoxicity in organisms at different trophic levels; (3) the impacted of ENPs and PPCPs on cellular-level biological process. This review elucidated the potential ecological hazards associated with the interaction of ENPs and PPCPs, and serves as a foundation for future investigations into the ecotoxicity and mode of action of ENPs, PPCPs, and their co-occurring metabolites.