Mass spectrometry-based proteomic applications in dental implants research
Tim Halstenbach1, Annika Topitsch1,2,3,4, Oliver Schilling2
1Department of Oral- and Craniomaxillofacial Surgery/Translational Implantology, Division of Regenerative Oral Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Proteomics. Clinical Applications
|February 11, 2024
Summary
Mass spectrometry-based proteomics offers new insights into dental implant research, aiding in understanding peri-implant tissues and identifying markers for diagnosing peri-implantitis. This approach helps differentiate healthy from diseased implants.
Area of Science:
- Oral biology
- Biomaterials science
- Proteomics
Background:
- Dental implants are widely used for tooth replacement.
- Research focuses on osseointegration, tissue grafting, and peri-implantitis.
- Increasing demand necessitates advanced research methods.
Purpose of the Study:
- To review the application of mass spectrometry (MS)-based proteomics in dental implant research.
- To highlight proteomics' role in understanding peri-implant tissue biology.
- To explore proteomics for diagnosing and differentiating peri-implant conditions.
Main Methods:
- Comprehensive literature review of MS-based proteomics in dental implantology.
- Analysis of studies investigating peri-implant soft and hard tissues.
- Evaluation of proteomics for identifying diagnostic markers.
Main Results:
- Proteomics provides insights into the biological processes of peri-implant tissues.
- MS-based proteomics aids in distinguishing between healthy and diseased implants.
- Potential new diagnostic markers for peri-implantitis have been identified.
Conclusions:
- MS-based proteomics is a valuable tool in dental implant research.
- It enhances understanding of peri-implant tissue responses and disease states.
- Recommendations for future research designs are provided.
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