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Effects of Ferulic Acid on Cognitive Function: A Systematic Review.
Yesim Karademir1, Alan Mackie1, Kieran Tuohy1
1School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK.
Molecular Nutrition & Food Research
|February 11, 2024
Summary
Ferulic acid (FA) shows promise in improving cognitive function, particularly in animal models of dementia. While beneficial effects were observed in healthy animals, further research is needed to confirm its impact on human cognition.
Area of Science:
- Neuroscience
- Pharmacology
- Nutritional Science
Background:
- Plant (poly) phenolic compounds, including Ferulic acid (FA), are linked to reduced dementia risk and preserved cognitive function during aging.
- Ferulic acid (FA) is widely available in common foods like cereals, fruits, vegetables, and coffee.
- This systematic review investigates the impact of Ferulic acid (FA) on cognitive performance in both human and animal subjects.
Approach:
- A comprehensive literature search was conducted across major scientific databases (Web of Science, Scopus, PubMed, OVID, CINAHL) up to October 2023.
- Search terms focused on Ferulic acid (FA) and cognitive functions (cognition, memory, attention, learning, recognition).
- Inclusion criteria were applied to filter relevant studies for systematic review.
Key Points:
- No human studies met the inclusion criteria for this review.
- Twenty-six animal studies were identified, with the majority (n=11) utilizing Alzheimer's disease models.
- Five studies examined Ferulic acid (FA) effects in healthy animal models.
Conclusions:
- Animal studies suggest Ferulic acid (FA) can ameliorate cognitive decline in disease models in a dose- and time-dependent manner.
- Ferulic acid (FA) demonstrated beneficial effects on cognitive function in healthy animals.
- Further investigation is necessary to ascertain the effects of Ferulic acid (FA) on human cognitive function.
