Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

975
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
975
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic Adaptation and Potential Regulatory Mechanisms of Longissimus Dorsi-Derived Skeletal Muscle Satellite Cells from Hu Sheep Under Insulin Induction.

Animals : an open access journal from MDPI·2026
Same author

Sex-specific signatures of gut microbiota and systemic inflammation in patients with urolithiasis: a cross-sectional study.

Frontiers in cellular and infection microbiology·2026
Same author

Light hydrogen isotopes in terrestrial core.

Science advances·2026
Same author

Adenoid-Nasopharyngeal Ratio and craniofacial growth in Children: A two-center longitudinal study with threshold and causal analyses.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Assessment of Papillary Thyroid Carcinoma by Profiling Multiple Matrix Metalloproteinase Activities Using a Machine Learning-Assisted Peptide Microarray Sensing Platform.

Analytical chemistry·2026
Same author

Crab Shell Inspired Chitin/β-Tricalcium Phosphate Screws as Orthopedic Implants.

Biomacromolecules·2026

Related Experiment Video

Updated: Jul 3, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K

Association Between Klotho Gene Polymorphisms and Urolithiasis: A Meta-Analysis.

Jiaxuan Qin1, Bo Duan1, Bowen Chen1

  • 1Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Fujian, China.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 11, 2024
PubMed
Summary

Klotho gene polymorphisms may influence urolithiasis risk. Specifically, Klotho rs1207568 adenine variant might decrease risk in Caucasians, while other variants show no significant association in Asian or Caucasian populations.

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K

Related Experiment Videos

Last Updated: Jul 3, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K

Area of Science:

  • Genetics and Molecular Biology
  • Nephrology

Background:

  • Previous research suggests a link between Klotho gene polymorphisms and urolithiasis (kidney stones).
  • Understanding this association is crucial for identifying genetic predispositions to kidney stone formation.

Approach:

  • A systematic meta-analysis was conducted to evaluate the relationship between Klotho gene polymorphisms and urolithiasis susceptibility.
  • Ten relevant studies were included, pooling odds ratios and 95% confidence intervals to determine effect sizes.

Key Points:

  • The Klotho rs1207568 adenine (A) polymorphism may be associated with a reduced risk of urolithiasis in Caucasian individuals.
  • No significant association was found between Klotho rs3752472 and urolithiasis risk in the Han Asian subgroup.
  • Klotho rs564481 and rs650439 polymorphisms did not show a significant relationship with urolithiasis risk in Asian or Caucasian populations.

Conclusions:

  • The Klotho gene, particularly the rs1207568 polymorphism, may play a role in urolithiasis risk, especially in Caucasians.
  • Further research is needed to elucidate the complex genetic factors contributing to urolithiasis across different ethnic groups.