Circulating blood circular RNA in Parkinson's Disease; a systematic study
Aleksandra Beric1,2, Yichen Sun1,2, Santiago Sanchez1,2
1Department of Psychiatry, Washington University in Saint Louis School of Medicine.
Medrxiv : the Preprint Server for Health Sciences
|February 12, 2024
Summary
Circular RNAs (circRNAs) show significant differences in Parkinson's disease (PD) patients. These findings highlight circRNAs as promising biomarkers for PD diagnosis and understanding disease mechanisms.
Area of Science:
- Genetics
- Neuroscience
- Biomarkers
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder with complex etiology.
- Identifying reliable biomarkers for early diagnosis and understanding disease mechanisms is crucial for effective management.
Approach:
- Utilized transcriptomic data from 1,848 participants across two large public studies.
- Performed cross-sectional and longitudinal (mixed-effects model) analyses to identify differentially expressed circRNAs.
- Validated findings across different populations, including mutation carriers and diverse ancestries.
Key Points:
- Identified 192 differentially expressed circRNAs in Parkinson's disease patients compared to healthy controls.
- Differential expression patterns were consistent across longitudinal analyses, mutation carriers, and diverse ancestries.
- A panel of 149 circRNAs achieved a Receiver Operating Characteristic Area Under the Curve (ROC AUC) of 0.825, indicating diagnostic potential.
Conclusions:
- Circular RNAs are significantly involved in the pathogenesis of Parkinson's disease.
- circRNAs demonstrate potential as robust diagnostic biomarkers for Parkinson's disease.
- Further research into circRNA function may reveal novel therapeutic targets for PD.
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