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Updated: Jul 8, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
Swelling Behavior of Novel Hydrogels Produced from Glucose-Based Ionic Monomers with Varying Cross-Linkers
Sina Lambrecht1, Henrik Schröter1, Henriette Pohle1
1Department Life, Light and Matter, University of Rostock, Albert-Einstein-Str. 25, Rostock 18059, Germany.
Abstract:
This work presents the synthesis of glucose-based vinyl imidazolium monomers and the hydrogels produced thereof. These novel semisynthetic, cationic hydrogels were prepared by radical polymerization with different types of commercial cross-linkers such as N,N'-methylenebis(acrylamide) or poly(ethylene glycol) diacrylate. Both the type and the amount of cross-linker were investigated as influencing factors with respect to the swelling degree. It was found that the cross-linker type majorly influences the swelling degree and long-term stability of the hydrogels. Last, the influence of different anions (e.g., halogens, acetate, and triflate) in the monomer molecule on the swelling properties of the hydrogels was investigated.
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