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Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug
Zuwu Tang1, Yuqing Yang1, Yuwei Pan1
1School of Materials and Packaging Engineering, Fujian Polytechnic Normal University, Fuzhou, Fujian 350300, P. R. China.
ACS Omega
|February 12, 2024
Summary
This study presents a novel poly(N-vinylpyrrolidone)/carboxymethyl cellulose) hydrogel. This biocompatible material offers excellent injectable and self-healing properties, ideal for advanced drug delivery systems.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Hydrogels are crucial in biomedicine, but injectable and self-healing variants are challenging to fabricate.
- Existing hydrogels often lack the desired combination of injectability, self-healing, and biocompatibility for advanced applications.
Purpose of the Study:
- To develop a biocompatible poly(N-vinylpyrrolidone)/carboxymethyl cellulose (PVP/CMC) hydrogel with enhanced injectable and self-healing capabilities.
- To investigate the hydrogel's properties, including swelling ratio, drug release capacity, and the influence of CMC concentration on these characteristics.
Main Methods:
- Fabrication of poly(N-vinylpyrrolidone)/carboxymethyl cellulose (PVP/CMC) hydrogels.
- Characterization of hydrogel properties: injectability, self-healing time, swelling ratio, and drug release kinetics.
- Evaluation of biocompatibility and drug release control by adjusting PVP/CMC ratio.
Main Results:
- The synthesized PVP/CMC hydrogel demonstrated excellent injectability and self-healing properties, with bisected hydrogels healing within 30 seconds.
- Hydrogel swelling ratio increased with CMC content, reaching a maximum of 2850% at a 1.0:1.5 PVP:CMC ratio.
- The hydrogel exhibited significant drug release capacity (up to 70%) with controlled release rates achievable by adjusting the PVP/CMC proportion.
Conclusions:
- The developed PVP/CMC hydrogel possesses a unique combination of biocompatibility, injectability, and rapid self-healing.
- This novel hydrogel shows great potential for controlled drug release applications due to its tunable properties and excellent drug release capacity.
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