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Updated: Jul 13, 2026

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
In vivo three-dimensional kinematic comparison of normal knees between flexion and extension activities
Kenichi Kono1,2, Takaharu Yamazaki3, Shuji Taketomi1
1Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background/Objective:
Normal knee kinematics during flexion and extension activities over the whole range of motion remains unknown. This study aimed to clarify in vivo kinematics during knee flexion and extension activities of normal knees by comparing continuous flexion and extension activities up to a high flexion angle.
Methods:
Twenty knees of 10 Japanese volunteers were enrolled in this study. Each volunteer performed a continuous squatting motion under fluoroscopy, and a two- or three-dimensional registration technique was used. Rotation and anteroposterior translation of the medial and lateral sides of the femur relative to the tibia at each flexion angle were evaluated.
Results:
Femoral external rotation was significantly smaller from 10° to 40° flexion during extension activities than during flexion activities. However, the femoral external rotation was larger from 120° to 130° flexion during extension activities than during flexion activities. From 10° to 60° of flexion, the medial side was significantly more posteriorly located during extension activities than during flexion activities. Furthermore, the lateral side was significantly more posteriorly located at 130° of flexion during extension activities than during flexion activities.
Conclusion:
In vivo kinematics of normal knees during extension activities differ from those during flexion activities in early and high flexion.
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