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Updated: Jul 3, 2025

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
Circumferential tracheal replacement with silicone stent supported, cryopreserved aortic homograft
Edward Hauptmann1, Shumon Dhar2, Omar Harirah1
1Department of Surgery, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd, Dallas, TX 75235, United States.
Abstract:
Treatment of long-segment tracheal defects remains a challenge in thoracic surgery with no standard surgical option. Aortic allografts have been used for this purpose with varying degrees of success. In a patient that suffered anastomotic dehiscence after tracheal resection with primary anastomosis, we performed complete tracheal resection and replacement using a stented circumferential aortic allograft. Currently, this patient is able to breathe normally without tracheostomy assistance 22 months postoperatively. Our report is the first in the English literature of long-term survival without tracheostomy dependence and close interval follow-up after circumferential tracheal resection and replacement with a cryopreserved aortic allograft.

