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Related Concept Videos

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

536
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
536
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

524
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
524

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Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
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USE OF ARTIFICIAL CELLS AS DRUG CARRIERS.

Sibel Emir Diltemiz1,2, Maryam Tavafoghi PhD1, Natan Roberto de Barros1,3

  • 1Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, California, USA.

Materials Chemistry Frontiers
|February 12, 2024
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Summary
This summary is machine-generated.

Artificial cells, inspired by natural cell membranes, offer advanced drug delivery systems (DDSs). These protocells provide effective, controlled therapeutic release for various diseases, promising greater impact in future treatments.

Keywords:
Artificial cellsdrug deliveryliposomestherapeutic drug delivery

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Area of Science:

  • Biomimetic chemistry
  • Synthetic biology
  • Materials science

Background:

  • Cells are fundamental biological units; mimicking their complexity is key for new therapeutic strategies.
  • Cell membrane-based drug delivery systems (DDSs), or artificial cells/protocells, are emerging technologies.
  • Artificial cells are created via top-down (natural system modification) or bottom-up (component assembly) approaches.

Purpose of the Study:

  • To review recent advancements in artificial cells as drug delivery systems.
  • To highlight designs inspired by natural cells and cell membranes.
  • To discuss the therapeutic potential and future impact of increasingly complex artificial cells.

Main Methods:

  • Review of current literature on artificial cell development.
  • Analysis of top-down and bottom-up fabrication strategies.
  • Examination of design principles derived from natural cellular structures.

Main Results:

  • Artificial cells are effective drug carriers with controlled release capabilities.
  • Designs are increasingly sophisticated, drawing inspiration from natural cell membranes.
  • These systems show promise for treating a range of diseases.

Conclusions:

  • Advancements in artificial cell technology yield potent drug carriers.
  • Mimicking natural cell complexity enhances therapeutic efficacy and control.
  • Future, more complex artificial cells will significantly impact therapeutic design.