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Updated: Jul 3, 2025
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Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
Published on: May 23, 2013
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Ocular motor and vestibular dysfunction in central nervous system lymphoma
Suk-Min Lee1, Seo Young Choi1, Jae-Hwan Choi2
1Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
European Journal of Neurology
|February 12, 2024
Summary
Abnormal vestibular and ocular motor findings are key indicators of central nervous system (CNS) lymphoma. Early neuro-ophthalmological and neuro-otological evaluation can aid in the diagnosis of this challenging condition.
Area of Science:
- Neuroscience
- Oncology
- Ophthalmology
Background:
- Diagnosis of central nervous system (CNS) lymphoma presents significant challenges.
- Ocular motor and vestibular abnormalities are not widely recognized as early indicators.
Purpose of the Study:
- To investigate the spectrum of abnormal vestibular and ocular motor findings in patients with CNS lymphoma.
- To determine the diagnostic utility of neuro-ophthalmological and neuro-otological examinations in CNS lymphoma.
Main Methods:
- Retrospective analysis of 30 patients diagnosed with CNS lymphoma and exhibiting ocular motor/vestibular abnormalities.
- Review of demographic, clinical, laboratory, radiological, and pathological data.
- Detailed examination of ocular motor and vestibular system findings.
Main Results:
- Diplopia (43%) and vestibular symptoms (50%) were common presentations.
- Abnormal ocular motor findings included nerve palsies and ophthalmoplegia.
- Vestibular abnormalities were often isolated, with CNS lymphoma affecting brainstem, cerebellum, and cranial nerves.
Conclusions:
- Neuro-ophthalmological and neuro-otological evaluations are crucial for the early diagnosis of CNS lymphoma.
- This study broadens the understanding of clinical and radiological manifestations of CNS lymphoma.
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