Renal Survival of Chronic Kidney Disease Patients in a Tertiary Referral Hospital in Malaysia

Area of Science:

• Nephrology
• Public Health
• Epidemiology

Background:

• Chronic kidney disease (CKD) is a significant global health concern, frequently advancing to end-stage renal disease (ESRD).
• Understanding renal survival time in CKD patients is crucial for effective management and public health strategies.

Purpose of the Study:

• To determine the renal survival time of patients diagnosed with chronic kidney disease (CKD).
• To identify factors influencing the progression of CKD to end-stage renal disease (ESRD).

Main Methods:

• A retrospective cohort study involving 247 CKD patients in a Malaysian tertiary referral hospital (2005-2015).
• Inclusion criteria: CKD patients dependent on dialysis; exclusion criteria: transferred patients and incomplete records.
• Renal survival time was calculated from CKD diagnosis to ESRD diagnosis or dialysis initiation.

Main Results:

• 193 (78.1%) CKD patients progressed to ESRD, with a mean age of 53 years.
• Hypertension (92.2%) and diabetes mellitus (85.5%) were the most prevalent comorbidities.
• The overall renal survival time to ESRD was 26 months (95% CI: 20.41, 31.59).
• Smoking, hyperlipidemia, and use of lipid-lowering agents were significantly associated with renal survival (P < 0.001).

Conclusions:

• CKD frequently progresses to ESRD, with a median survival of 26 months post-diagnosis.
• Early detection and management of CKD are vital for improving patient outcomes and prolonging renal survival.
• Risk factors such as smoking and hyperlipidemia require attention in CKD patient management.