Systemic immune- inflammation index predicts post-MI left ventricular remodeling.

Area of Science:

• Cardiology
• Biomarkers
• Inflammation

Background:

• Left ventricular (LV) remodeling post-myocardial infarction (MI) is influenced by the inflammatory response.
• The systemic immune-inflammation index (SII) is a novel marker associated with coronary artery disease.

Purpose of the Study:

• To investigate the predictive value of SII for LV remodeling in patients with ST-elevation myocardial infarction (STEMI).

Main Methods:

• The study included 528 STEMI patients.
• Patients were classified as remodelers or non-remodelers based on left ventricular end-diastolic volume (LVEDV) changes within 12 months.
• Univariate and multivariate logistic regression analyses were performed.

Main Results:

• Higher SII values were associated with increased LVEDV in univariate analysis.
• Multivariate analysis confirmed SII as an independent predictor of LV remodeling.
• An SII cut-off value of 613.3 or higher significantly correlated with LV remodeling.

Conclusions:

• SII is a simple, affordable biomarker for cardiovascular diseases.
• SII may serve as a valuable tool for predicting LV remodeling in STEMI patients.