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Updated: Jul 3, 2025

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Developmental Assessment in Neonatal Hypernatremic Dehydration Cohort at 18-30 months of Age Using DASII Score

Damini Sharma1, Anurag Singh2, Arushi Singhal2

  • 1Department of Pediatrics, Dr SN Medical College, Jodhpur, Rajasthan, India. dendeavours@gmail.com.

Indian Journal of Pediatrics
|February 12, 2024
PubMed

Insights

Neonatal hypernatremic dehydration can cause developmental delays in infants. Brain imaging abnormalities and severe dehydration strongly correlate with poor developmental outcomes, particularly affecting motor skills.

Area of Science:

  • Neonatalogy
  • Pediatric Neurology
  • Developmental Pediatrics

Background:

  • Neonatal hypernatremic dehydration is a critical condition.
  • The long-term neurodevelopmental effects require further investigation.

Purpose of the Study:

  • To assess the developmental outcomes in infants with a history of neonatal hypernatremic dehydration.
  • To correlate developmental outcomes with brain imaging findings and severity of hypernatremia.

Main Methods:

  • Developmental assessment using the Developmental Assessment Scale for Indian Infants (DASII) at 18-30 months.
  • Comparison of 45 infants with neonatal hypernatremic dehydration to 45 controls.
  • Analysis of brain lesions via magnetic resonance imaging (MRI).

Main Results:

  • Seven percent of the study group exhibited developmental delay at 24 months.
  • Severity of hypernatremia strongly correlated with poor developmental outcomes (p=0.001).
  • Abnormal MRI patterns strongly correlated with poor developmental outcomes (p=0.001).
  • Motor scores were more affected than mental scores.

Conclusions:

  • The neonatal brain is vulnerable to hypernatremic dehydration, leading to developmental delays.
  • Brain imaging findings and hypernatremia severity are significant predictors of neurodevelopmental outcomes.
  • Early identification and management are crucial for improving long-term outcomes.

Keywords:
DASII scoreDevelopmental delayNeonatal hypernatremic dehydrationNeurodevelopmental follow-up

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