Related Experiment Video
Updated: Jul 3, 2025
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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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Thyroid disorders induced by immune checkpoint inhibitors.
Dimitra Karaviti1, Eleni-Rafaela Kani1, Eleftheria Karaviti1
1Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Endocrine
|February 12, 2024
Summary
Immune checkpoint inhibitors (ICIs) can cause thyroid dysfunction as a side effect. This review covers patterns, diagnosis, and management of ICI-induced thyroid issues for better patient care.
Area of Science:
- Oncology
- Immunology
- Endocrinology
Background:
- Immune checkpoint inhibitors (ICIs) are vital cancer therapies that harness the immune system.
- Immune-related adverse effects (irAEs), particularly endocrinopathies, are common with ICI use.
- Thyroid dysfunction is a frequent endocrinopathy associated with ICI therapy.
Purpose of the Study:
- To review the significance of ICI-induced thyroid dysfunction.
- To explore its patterns, mechanisms, diagnosis, and treatment.
- To highlight factors influencing dysfunction risk.
Main Methods:
- Literature review on ICI-induced thyroid dysfunction.
- Analysis of pathophysiological mechanisms, including destructive thyroiditis.
- Summary of diagnostic and therapeutic strategies.
Main Results:
- Thyroid dysfunction manifests as thyrotoxicosis, hypothyroidism, or both.
- Diagnosis involves clinical, laboratory, and imaging assessments.
- Treatment varies from levothyroxine substitution to beta blockers.
Conclusions:
- Effective recognition and management of ICI-induced thyroid dysfunction are crucial for patient safety and outcomes.
- Understanding influencing factors like cancer type and ICI dosage is important.
- This review provides a comprehensive guide for clinicians managing these complications.
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