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The visual impact of higher-order aberrations in patients with pediatric blepharokeratoconjunctivitis

Carolina Mendoza-Zamora1, Sara Gonzalez-Godinez1, Gustavo Ortiz-Morales1

  • 1Tecnologico de Monterrey, School of Medicine and Health Sciences. Institute of Ophthalmology and Visual Sciences, Av. Batallon de San Patricio #112. Col. Real de San Agustin, N.L., CP. 66278, Monterrey, Mexico.

International Ophthalmology
|February 12, 2024
PubMed

Insights

Pediatric blepharokeratoconjunctivitis (PBKC) significantly increases higher-order aberrations (HOAs), negatively impacting visual quality. Corneal changes like opacity and scarring correlate with these vision-impairing aberrations in children.

Area of Science:

  • Ophthalmology
  • Pediatric Eye Care
  • Corneal Disease

Background:

  • Pediatric blepharokeratoconjunctivitis (PBKC) is a common inflammatory condition affecting the eyelids and conjunctiva in children.
  • Understanding its impact on ocular optics and visual function is crucial for effective management.

Purpose of the Study:

  • To investigate and compare higher-order aberrations (HOAs) in children with PBKC versus healthy controls.
  • To analyze the visual consequences of these HOAs in the pediatric PBKC cohort.

Main Methods:

  • A prospective case-control study involving pediatric patients (≤16 years) with and without PBKC.
  • Wavefront aberrometry was utilized to quantify HOAs and assess visual quality metrics.

Main Results:

  • PBKC eyes exhibited significantly higher mean HOAs (1.05 ± 1.7mm) compared to controls (0.41 ± 0.18mm).
  • Reduced corrected-distance visual acuity (CDVA) (0.24 logMAR vs. 0.07 logMAR) and lower modulation transfer function (MTF) were observed in the PBKC group.
  • Corneal pathologies such as leukomas, vascularization, scarring, and pannus formation were associated with increased HOAs.

Conclusions:

  • Eyes with PBKC demonstrate a significant elevation in HOAs compared to healthy eyes.
  • Corneal opacity, vascularization, and scarring are linked to increased HOAs in PBKC.
  • Specific aberrations (coma, secondary astigmatism, quadrafoil, pentafoil) in PBKC eyes correlate with diminished CDVA and overall visual quality.
Abstract

Keywords:
BlepharokeratoconjunctivitisChildhood rosaceaChronic blepharitisHigher-order aberrationsWavefront aberrometry

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