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Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
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A self-stiffening compliant intracortical microprobe.

Naser Sharafkhani1, John M Long1, Scott D Adams1

  • 1School of Engineering, Deakin University, Geelong, VIC, 3216, Australia.

Biomedical Microdevices
|February 12, 2024
PubMed
Summary

This study introduces a novel flexible intracortical microprobe with compressible structures. It enables adjustable stiffness for precise neural insertion and adaptive brain interfacing, minimizing tissue damage.

Keywords:
3D printingBucklingFinite element methodInsertionIntracortical microprobeSelf-stiffening

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Flexible intracortical microprobes reduce brain tissue damage from micromotion.
  • Current bio-dissolvable coatings offer temporary stiffness but lack adjustable positioning control.
  • Irreversible dissolving processes prevent correction of microprobe positioning errors.

Purpose of the Study:

  • To propose a novel intracortical microprobe with dual compressible structures.
  • To enable adaptive brain interfacing and controlled insertion stiffness.
  • To achieve high-accuracy microprobe positioning with minimal tissue damage.

Main Methods:

  • Incorporating two compressible structures within the microprobe design.
  • Utilizing an inserter to apply compressive force, increasing elastic modulus.
  • Employing two-photon polymerization for 3D printing the microprobe.
  • Simulating microprobe insertion and operation with surrounding neural tissue.

Main Results:

  • The microprobe achieves instant switching between stiff and soft modes.
  • Operating elastic modulus is ≈23 kPa, 42% lower than existing probes.
  • Resulting maximum strain on surrounding tissue is reduced by ≈46%.
  • Experimental validation and successful insertion into a lamb brain without buckling.

Conclusions:

  • The proposed microprobe design offers adjustable stiffness for precise neural implantation.
  • The design significantly reduces tissue strain during brain micromotion.
  • This innovation enhances the safety and efficacy of intracortical neural interfaces.