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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Understanding the Symptoms and Impacts Experienced by People with Relapsing-Remitting MS: A Qualitative Investigation

Amy Barrett¹, Oyebimpe Olayinka-Amao¹, Tjalf Ziemssen²

¹Patient-Centered Outcomes Assessment, RTI Health Solutions, Research Triangle Park, NC, USA.

Neurology and Therapy

|February 12, 2024

Summary

Patient experiences with multiple sclerosis (MS) reveal significant impacts on daily life, particularly fatigue and mobility issues. Patient-reported outcome measures are crucial for capturing these MS symptoms and impacts effectively.

Keywords:

Fatigue Impacts Multiple sclerosis PROMIS MS Patient-reported outcomes Physical function Physical impairment Symptoms

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Published on: September 9, 2022

Area of Science:

Neurology
Patient-Reported Outcomes
Quality of Life Research

Background:

Multiple sclerosis (MS) is a disabling neurological condition with varied clinical presentations.
Standard clinical assessments may not fully capture the comprehensive impact of MS on patients' quality of life.
Patient-reported outcome (PRO) measures offer a valuable complement to clinical assessments for understanding MS disease state and impact.

Purpose of the Study:

To explore the lived experiences of individuals with relapsing-remitting MS.
To identify key symptoms and their impact on daily life for people with MS.
To develop a conceptual model illustrating MS outcomes based on patient experiences and existing literature.

Main Methods:

Conducted a literature review of studies on the experiences of people with MS.
Performed semi-structured concept elicitation interviews with 14 individuals diagnosed with relapsing-remitting MS in the USA.
Synthesized findings from the literature review and interviews to develop a conceptual model.

Main Results:

The study included 14 participants with a mean age of 43.9 years, predominantly White (78.6%) and female (78.6%).
Most bothersome symptoms reported were fatigue (n=9), cognitive dysfunction (n=5), and mobility/walking difficulties (n=3).
Key impacts on daily life included balance problems (n=13), work productivity (n=12), difficulty walking (n=11), daily activities (n=11), and leisure activities (n=10).

Conclusions:

A high frequency of concepts related to physical function, fatigue, and sensory-motor actions were identified.
A conceptual model was developed, integrating patient-reported symptoms, impairments, impacts, and known disease processes.
The model supports the use of PRO instruments like PROMIS Fatigue (MS) 8a and PROMIS Physical Function (MS) 15a to assess meaningful MS symptoms and impacts.