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Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

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Injectable extracellular matrix-mimetic hydrogel based on electrospun Janus fibers.

Jinzhong Zhang1, Xiaolong Zha2, Gengxin Liu3

  • 1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. lszha@dhu.edu.cn.

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Researchers developed an injectable ECM-mimetic hydrogel (IEMH) that mimics natural tissue structure. This new hydrogel supports cell growth and nutrient transport, showing promise for biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Existing injectable hydrogels fail to replicate the fibrous extracellular matrix (ECM) architecture.
  • Lack of ECM-like micro-pores hinders nutrient and waste transport in current hydrogels.
  • These limitations restrict the biological efficacy of injectable hydrogels for cell growth and phenotype maintenance.

Purpose of the Study:

  • To fabricate an injectable ECM-mimetic hydrogel (IEMH) that overcomes the limitations of current biomaterials.
  • To create a hydrogel with enhanced structural mimicry of the natural ECM.
  • To develop a hydrogel suitable for biomedical applications requiring facile cell interaction and transport.

Main Methods:

  • Janus fibers capable of self-curling at body temperature were shortened and dispersed.
  • Mass production of IEMH was achieved via side-by-side electrospinning and UV irradiation.
  • Characterization included SEM, TIRFM, NMR, and FTIR to analyze sol-gel transition mechanisms.

Main Results:

  • The IEMH demonstrated sol-gel transition at body temperature with 5 wt% fibers, forming stable, elastic, and self-healing gels.
  • The hydrogel exhibited desirable pseudoplasticity for room-temperature injection.
  • Characterization confirmed sol-gel transition due to fiber entanglement and hydrophobic interactions.
  • In vitro cytotoxicity assays showed over 95% cell viability for C2C12 myoblasts.

Conclusions:

  • The developed IEMH successfully mimics the fibrous ECM architecture and micro-pore structure.
  • The hydrogel possesses excellent injectability, stability, and self-healing properties.
  • The IEMH shows high biocompatibility and potential for diverse biomedical applications.