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Plasma fibrinogen: a driver of left ventricular remodeling in patients undergoing peritoneal dialysis and its related

Yun Chen1, Shuqi Dai1, Xiaolin Ge1

  • 1Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

Renal Failure
|February 12, 2024
PubMed

Insights

Elevated plasma fibrinogen is linked to left ventricular hypertrophy progression in peritoneal dialysis patients. Risk factors for high fibrinogen include older age, high glucose, cholesterol, and hsCRP.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Plasma fibrinogen is a known risk factor for cardiovascular mortality in peritoneal dialysis (PD) patients.
  • Left ventricular (LV) remodeling and function are critical in PD patients.
  • Understanding fibrinogen's role in LV remodeling is essential for managing cardiovascular risk.

Purpose of the Study:

  • To investigate the association between plasma fibrinogen levels and left ventricular (LV) remodeling and function in PD patients.
  • To identify risk factors associated with elevated fibrinogen levels in this population.

Main Methods:

  • Adult PD patients (n=278) were recruited and followed for two years.
  • Echocardiography assessed LV structure and function; correlation and regression analyses identified associations.
  • Logistic regression and ROC curves determined fibrinogen's role in LV hypertrophy (LVH) progression.

Main Results:

  • Higher fibrinogen levels correlated with increased LV mass index (LVMI), mean wall thickness (MWT), and relative wall thickness (RWT).
  • An elevated E/A ratio was negatively associated with fibrinogen levels.
  • Fibrinogen was an independent risk factor for LVH progression; age, total cholesterol, fasting blood glucose, and hsCRP were associated with higher fibrinogen.

Conclusions:

  • Elevated plasma fibrinogen is independently associated with LVH progression in PD patients.
  • Older age, higher fasting blood glucose, total cholesterol, and hsCRP are risk factors for elevated fibrinogen levels.
Abstract

Keywords:
Cardiovascular risksfibrinogeninflammationleft ventricular hypertrophyperitoneal dialysis

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