JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

The clinical significance of indeterminate pulmonary nodules in patients with primary bone sarcoma: a systematic review

  • 0College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
The British Journal of Radiology +

|

February 12, 2024

|

February 12, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Indeterminate pulmonary nodules (IPNs) in primary bone cancer patients can progress to metastasis at a significant rate. Early CT monitoring is recommended, especially for larger nodules, to manage this risk.

Area Of Science

  • Oncology
  • Pulmonary Medicine
  • Radiology

Background

  • Indeterminate pulmonary nodules (IPNs) are a clinical challenge in patients with primary bone sarcomas.
  • Understanding the incidence and progression of IPNs to metastasis is crucial for patient management.

Approach

  • A systematic review and pooled quantitative analysis of six studies involving 1667 patients.
  • Searched Medline, Embase, and Cochrane Library databases for eligible English-language articles up to 2023.
  • Utilized the Newcastle-Ottawa Quality Assessment Form to evaluate the risk of bias in included cohort studies.

Key Points

  • The incidence of IPNs in primary bone cancer patients was 18.1%.
  • 45.0% of IPNs progressed to metastasis.
  • Nodule size (>5mm), number (≥4), bilateral distribution, incomplete calcification, and lobulated margins were associated with increased metastasis risk.

Conclusions

  • The risk of IPNs progressing to metastasis in primary bone sarcoma patients is substantial.
  • Large IPNs (>5mm) carry a high risk of being actual metastases.
  • A minimum of 2-year follow-up with serial CT imaging (3, 6, 12-month intervals) is suggested for these patients.

Keywords: