Urinary cancer detection by the target urine volatile organic compounds biosensor platform

Vichayut Suthat Na Ayutaya ¹, Chaianan Tantisatirapoon ², Sekdusit Aekgawong ²

⁰School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

Scientific Reports +

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February 12, 2024

View abstract on PubMed

Summary

Volatile organic compounds (VOCs) in urine show promise for noninvasive genitourinary cancer detection. Specific VOCs like methane and ethanol, detected by metal oxide biosensors, can significantly predict cancer presence.

Area Of Science

Biomedical Engineering
Analytical Chemistry
Oncology

Background

Volatile organic compounds (VOCs) are increasingly important for noninvasive cancer diagnostics.
Metal oxide biosensor platforms offer a promising avenue for detecting VOCs in biological samples like urine.

Purpose Of The Study

To evaluate the feasibility of a metal oxide biosensor platform for detecting genitourinary cancers using urine VOCs.
To identify specific VOC biomarkers indicative of genitourinary malignancies.

Main Methods

Utilized five commercial semiconductor sensors to detect various VOCs in urine samples.
Analyzed changes in electrical resistance related to VOC metabolism at a 2000 mV heater voltage.
Employed logistic regression and Receiver Operating Characteristic (ROC) analysis for biomarker evaluation.

Main Results

Methane, iso-butane, hydrogen, and ethanol VOCs demonstrated significant predictive capability for genitourinary cancer (P=0.013).
ROC analysis confirmed the statistical significance of these VOCs in disease prediction (P<0.05).
The study included 64 participants: 32 with genitourinary cancer and 32 controls.

Conclusions

Methane, iso-butane, hydrogen, and ethanol in urine show potential as biomarkers for genitourinary cancer diagnosis.
Developing targeted gas metal oxide sensors for these VOCs could lead to innovative, noninvasive cancer detection tools.

Keywords:

Biosensor Genitourinary cancer VOCs