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Urinary cancer detection by the target urine volatile organic compounds biosensor platform
Vichayut Suthat Na Ayutaya1, Chaianan Tantisatirapoon2, Sekdusit Aekgawong2
1School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Scientific Reports
|February 12, 2024
Summary
Volatile organic compounds (VOCs) in urine show promise for noninvasive genitourinary cancer detection. Specific VOCs like methane and ethanol, detected by metal oxide biosensors, can significantly predict cancer presence.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Oncology
Background:
- Volatile organic compounds (VOCs) are increasingly important for noninvasive cancer diagnostics.
- Metal oxide biosensor platforms offer a promising avenue for detecting VOCs in biological samples like urine.
Purpose of the Study:
- To evaluate the feasibility of a metal oxide biosensor platform for detecting genitourinary cancers using urine VOCs.
- To identify specific VOC biomarkers indicative of genitourinary malignancies.
Main Methods:
- Utilized five commercial semiconductor sensors to detect various VOCs in urine samples.
- Analyzed changes in electrical resistance related to VOC metabolism at a 2000 mV heater voltage.
- Employed logistic regression and Receiver Operating Characteristic (ROC) analysis for biomarker evaluation.
Main Results:
- Methane, iso-butane, hydrogen, and ethanol VOCs demonstrated significant predictive capability for genitourinary cancer (P=0.013).
- ROC analysis confirmed the statistical significance of these VOCs in disease prediction (P<0.05).
- The study included 64 participants: 32 with genitourinary cancer and 32 controls.
Conclusions:
- Methane, iso-butane, hydrogen, and ethanol in urine show potential as biomarkers for genitourinary cancer diagnosis.
- Developing targeted gas metal oxide sensors for these VOCs could lead to innovative, noninvasive cancer detection tools.
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