Adiposity associates with lower plasma resolvin E1 (Rve1): a population study

Area of Science:

• Biochemistry
• Immunology
• Cardiovascular Science

Background:

• Inadequate inflammation resolution contributes to chronic low-grade inflammation.
• Specialized Pro-resolving Mediators (SPM), derived from fatty acids, actively resolve inflammation.
• Persistent inflammation is linked to numerous chronic conditions.

Purpose of the Study:

• To investigate plasma SPM levels in relation to sex, lifestyle, and cardiovascular disease (CVD) risk factors.
• To explore the association between specific SPM and measures of adiposity.

Main Methods:

• Plasma SPM and pathway intermediates were quantified using liquid chromatography-tandem mass spectrometry (LCMSMS).
• Statistical analyses included Pearson correlations, multiple regression, and t-tests/ANOVA.
• The study involved 978 27-year-olds from the Australian Raine Study.

Main Results:

• Women exhibited higher 17-HDHA and lower RvE1 and RvD1 levels compared to men.
• Obesity was associated with lower RvE1, while smoking and higher alcohol consumption correlated with increased RvE1.
• Plasma RvE1 showed a negative association with various adiposity measures (BMI, waist circumference, abdominal fat).

Conclusions:

• A deficiency in plasma RvE1 may be associated with increasing adiposity.
• This RvE1 deficiency could be relevant to the chronic inflammation observed in CVD and other diseases.