Jove
Visualize
Contact Us

Related Experiment Videos

Chemoreceptor reflexes and cardiovascular control.

M de Burgh Daly

    Acta Physiologica Polonica
    |January 1, 1985
    PubMed
    Summary

    Stimulating peripheral arterial chemoreceptors, like the carotid bodies, triggers bradycardia and vasoconstriction. These responses, mediated by alpha-adrenergic fibers, may contribute to neurogenic hypertension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of pulmonary C-fibre afferent stimulation on cardiac vagal neurones in the nucleus ambiguus in anaesthetized cats.

    The Journal of physiology·2000
    Same author

    Cardiovascular responses to carotid chemoreceptor stimulation in the dog: their modulation by urinary bladder distension.

    The Journal of physiology·2000
    Same author

    Trigeminal and carotid body inputs controlling vascular resistance in muscle during post-contraction hyperaemia in cats.

    The Journal of physiology·1999
    Same author

    Reflex cardiac dromotropic responses to stimulation of the carotid and aortic chemoreceptors in the anaesthetized cat.

    The Journal of physiology·1997
    Same author

    Effects of distension of the urinary bladder on the cardiovascular reflexes from the carotid baroreceptors in the dog.

    The Journal of physiology·1993
    Same author

    A morphological study of the size of the vascular compartment of the carotid body in a non-human primate (Cercopithecus ethiopus), and a comparison with the cat and rat.

    Acta anatomica·1993
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Cardiovascular Physiology
    • Neuroscience
    • Respiratory Regulation

    Background:

    • Peripheral arterial chemoreceptors (PACs) monitor blood oxygen and carbon dioxide levels.
    • PACs play a role in cardiovascular and respiratory control.
    • The specific vascular effects and their contribution to hypertension are not fully elucidated.

    Purpose of the Study:

    • To investigate the cardiovascular responses to stimulation of carotid body and aortic body chemoreceptors.
    • To determine the neural pathways mediating these vascular effects.
    • To explore the potential role of PACs in the neurogenic component of hypertension.

    Main Methods:

    • Controlled pulmonary ventilation in experimental models.
    • Stimulation of carotid body and aortic body chemoreceptors.
    • Measurement of heart rate, arterial blood pressure, and peripheral vascular resistance.
    • Assessment of neural mediation via alpha-adrenergic pathways.

    Main Results:

    • Carotid body chemoreceptor stimulation induced bradycardia and peripheral vasoconstriction.
    • Aortic body stimulation resulted in bradycardia or tachycardia and peripheral vasoconstriction.
    • These PAC-mediated vascular effects are transmitted via alpha-adrenergic sympathetic fibers.
    • Responses can be modulated by respiration, blood pressure, and central nervous system activity.

    Conclusions:

    • PACs elicit significant cardiovascular reflexes, including bradycardia and vasoconstriction.
    • Alpha-adrenergic pathways are crucial for mediating PAC-induced vascular changes.
    • PACs represent a potential mechanism contributing to the neurogenic component of hypertension.

    Related Experiment Videos