A retrospective study for long-term oncologic and obstetric outcomes in cervical intraepithelial neoplasia treated with loop electrosurgical excision procedure: focus on surgical margin and human papillomavirus
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View abstract on PubMed
Summary
This summary is machine-generated.Loop electrosurgical excision (LEEP) for cervical intraepithelial neoplasia (CIN) can lead to recurrence, with positive HPV status and margins being key risk factors. While LEEP impacts obstetric outcomes, a history of preterm birth is the main predictor for delivery complications.
Area Of Science
- Gynecology
- Oncology
- Obstetrics
Background
- Cervical intraepithelial neoplasia (CIN) is a precancerous condition of the cervix.
- Loop electrosurgical excision procedure (LEEP) is a common treatment for CIN.
- Long-term oncological and obstetric outcomes after LEEP require further evaluation.
Purpose Of The Study
- To assess the long-term oncological and obstetric results of LEEP for CIN.
- To identify risk factors for recurrence and preterm birth post-LEEP.
Main Methods
- Retrospective cohort study of 385 patients undergoing LEEP for CIN 2-3 (2011-2019).
- Analysis of demographic data, histopathology, postoperative cytology, and HPV status.
- Cox proportional hazards model and Kaplan-Meier curves for risk factor analysis.
Main Results
- Treatment failure (recurrence/residual disease) occurred in 13.5% of patients.
- Positive surgical margins and postoperative HPV detection were independent risk factors for treatment failure.
- A history of preterm birth was associated with preterm delivery; duration since LEEP correlated with preterm complications.
Conclusions
- Post-LEEP HPV status and margin status are independent predictors of treatment failure in CIN patients.
- Combining HPV and margin status did not enhance recurrence prediction accuracy.
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