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Salivary Sex Steroid Levels in Infants and the Relation with Infantile Colic

Fulya Mete Kalaycı1, Özlem Gürsoy Doruk2, İbrahim Mert Erbaş3

  • 1Dokuz Eylül University Faculty of Medicine, Department of Pediatrics, İzmir, Turkey

Journal of Clinical Research in Pediatric Endocrinology
|February 13, 2024
PubMed

Insights

Infantile colic in newborns may be linked to altered sex steroid production during minipuberty. This study found correlations between salivary estradiol and BMI in females with colic, and testosterone levels and sampling time in males with colic.

Area of Science:

  • Pediatric Endocrinology
  • Neonatal Research
  • Reproductive Biology

Background:

  • The hypothalamic-pituitary-gonadal axis is active during early infancy (minipuberty).
  • Infantile colic is a common neonatal condition with an unknown etiology.
  • The potential link between minipuberty hormonal activity and infantile colic has not been previously explored.

Purpose of the Study:

  • To investigate the relationship between infantile colic and sex steroid levels during minipuberty.
  • To determine if salivary testosterone and estradiol levels differ in infants with and without colic.
  • To explore correlations between sex steroids, body mass index, and sampling time in relation to infantile colic.

Main Methods:

  • Saliva samples were collected from 139 infants aged 15-60 days.
  • Infants were categorized into Group 1 (infantile colic, n=68) and Group 2 (healthy controls, n=71).
  • Salivary estradiol (Esal) in females and testosterone (Tsal) in males were quantified using ELISA.

Main Results:

  • Overall Tsal and Esal levels were similar between infants with and without colic.
  • In females with colic, Esal showed a positive correlation with body mass index (BMI) standard deviation scores.
  • In males with colic, Tsal levels were significantly correlated with later sampling times.

Conclusions:

  • While overall sex steroid levels were comparable, specific correlations suggest altered sex steroid dynamics in infants with colic.
  • Estradiol may be associated with BMI in female infants experiencing colic.
  • Testosterone levels in males with colic appear influenced by the time of day.
  • These findings indicate that sex steroid production might be affected during minipuberty in infants with infantile colic.
Abstract

Keywords:
Gonadal activityfussingnewbornpuberty

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