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Coated Blade Spray Ion Mobility Spectrometry.

Christian Thoben1, Jannie J Stadtler1, Paul R Simon1

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Coated blade spray (CBS) coupled with ion mobility spectrometry (IMS) offers rapid analysis of complex samples. This novel technique successfully detected drugs in beverages and pesticides in water, demonstrating its analytical potential.

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Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Spectrometry

Background:

  • Coated blade spray (CBS) integrates analyte extraction and electrospray ionization (ESI) on a single device.
  • Existing CBS applications are limited to mass spectrometry (MS).
  • Ion mobility spectrometry (IMS) offers compact, rapid ion separation based on mobility in a drift gas.

Purpose of the Study:

  • To couple Coated Blade Spray (CBS) with an established Electrospray Ionization-Ion Mobility Spectrometry (ESI-IMS) system.
  • To evaluate the feasibility of the integrated CBS-IMS for analyzing real-world samples.
  • To demonstrate the potential of CBS-IMS for sensitive and selective analyte detection.

Main Methods:

  • Integration of a selective polymer-coated metal blade (CBS) with a compact ESI-IMS instrument (75 mm drift length, R_P = 100).
  • Direct ESI from the CBS blade for ion introduction into the IMS.
  • Analysis of benzodiazepines and ketamine in beverage samples.
  • Analysis of the pesticide isoproturon in water samples.

Main Results:

  • Demonstrated the successful coupling of CBS with ESI-IMS.
  • Achieved preliminary measurements showcasing the system's performance.
  • Successfully detected target analytes (benzodiazepines, ketamine, isoproturon) in complex matrices.
  • Confirmed the feasibility of CBS-IMS for practical analytical applications.

Conclusions:

  • The developed CBS-IMS system is a viable technique for rapid and selective analysis.
  • This integration expands the application range of CBS technology.
  • CBS-IMS holds promise for sensitive detection in complex sample matrices like beverages and environmental water.