Related Experiment Video
Updated: Jul 3, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
268
Primary sclerosing cholangitis and pancreatic cancer: A retrospective cohort study of United States veterans
Anita Nguyen1,2, Babak Torabi Sagvand1,3, Madeline Alizadeh1,4
1Department of Veterans Affairs, Veterans Affairs (VA) Maryland Health Care System, Baltimore, MD, United States.
Frontiers in Gastroenterology (Lausanne, Switzerland)
|February 13, 2024
Summary
Veterans with primary sclerosing cholangitis (PSC) have a higher risk of pancreatic cancer, especially those without inflammatory bowel disease (IBD). Further research is needed to explore screening benefits for PSC patients.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Primary sclerosing cholangitis (PSC) is linked to hepatobiliary and colorectal cancers.
- The association between PSC and pancreatic cancer risk is uncertain, with conflicting evidence from European studies.
- Previous studies often did not adequately consider the presence or absence of concomitant inflammatory bowel disease (IBD).
Purpose of the Study:
- To investigate the prevalence of pancreatic cancer in United States veterans diagnosed with PSC.
- To compare pancreatic cancer prevalence in PSC patients with and without concurrent IBD.
- To assess pancreatic cancer risk in PSC patients relative to IBD patients and the general veteran population.
Main Methods:
- Retrospective study utilizing the Veterans Affairs (VA) Corporate Data Warehouse.
- Identification of patients using International Classification of Diseases, Tenth Revision (ICD-10) codes for PSC, IBD, and pancreatic cancer.
- Logistic regression analysis to control for confounding factors including age, gender, chronic pancreatitis, diabetes mellitus, and tobacco/alcohol use.
Main Results:
- A total of 946 PSC patients were identified among over 9 million veterans; 51.4% had concurrent IBD.
- Adjusted analysis revealed a significantly higher prevalence of pancreatic cancer in PSC patients (2.4%) compared to those with IBD only (0.5%) and the general veteran population (0.2%).
- The prevalence of pancreatic cancer was notably higher in PSC patients without concomitant IBD.
Conclusions:
- Veterans with PSC exhibit a high prevalence of pancreatic cancer, particularly those without IBD, when compared to the general veteran population.
- These findings underscore the need for further investigation into pancreatic cancer screening for PSC patients.
- Multicenter prospective studies are recommended to evaluate the benefits of early pancreatic cancer detection in individuals with PSC.
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
92
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
92
01:24Chronic Pancreatitis I: Introduction
89
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
89