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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Primary Sclerosing Cholangitis And Pancreatic Cancer: A Retrospective Cohort Study Of United States Veterans.

Primary sclerosing cholangitis and pancreatic cancer: A retrospective cohort study of United States veterans.

Anita Nguyen1,2, Babak Torabi Sagvand1,3, Madeline Alizadeh1,4

  • 1Department of Veterans Affairs, Veterans Affairs (VA) Maryland Health Care System, Baltimore, MD, United States.

Frontiers in Gastroenterology (Lausanne, Switzerland)
|February 13, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Veterans with primary sclerosing cholangitis (PSC) have a higher risk of pancreatic cancer, especially those without inflammatory bowel disease (IBD). Further research is needed to explore screening benefits for PSC patients.

Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Primary sclerosing cholangitis (PSC) is linked to hepatobiliary and colorectal cancers.
  • The association between PSC and pancreatic cancer risk is uncertain, with conflicting evidence from European studies.
  • Previous studies often did not adequately consider the presence or absence of concomitant inflammatory bowel disease (IBD).

Purpose of the Study:

  • To investigate the prevalence of pancreatic cancer in United States veterans diagnosed with PSC.
  • To compare pancreatic cancer prevalence in PSC patients with and without concurrent IBD.
  • To assess pancreatic cancer risk in PSC patients relative to IBD patients and the general veteran population.

Main Methods:

  • Retrospective study utilizing the Veterans Affairs (VA) Corporate Data Warehouse.
Keywords:
IBDPSCinflammatory bowel diseasepancreatic adenocarcinoma

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  • Identification of patients using International Classification of Diseases, Tenth Revision (ICD-10) codes for PSC, IBD, and pancreatic cancer.
  • Logistic regression analysis to control for confounding factors including age, gender, chronic pancreatitis, diabetes mellitus, and tobacco/alcohol use.

    • Main Results:

    • A total of 946 PSC patients were identified among over 9 million veterans; 51.4% had concurrent IBD.
    • Adjusted analysis revealed a significantly higher prevalence of pancreatic cancer in PSC patients (2.4%) compared to those with IBD only (0.5%) and the general veteran population (0.2%).
    • The prevalence of pancreatic cancer was notably higher in PSC patients without concomitant IBD.

    Conclusions:

    • Veterans with PSC exhibit a high prevalence of pancreatic cancer, particularly those without IBD, when compared to the general veteran population.
    • These findings underscore the need for further investigation into pancreatic cancer screening for PSC patients.
    • Multicenter prospective studies are recommended to evaluate the benefits of early pancreatic cancer detection in individuals with PSC.
    pancreatic cancer
    primary sclerosing cholangitis
    veteran