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Causal relationship between gut microbiota and hidradenitis suppurativa: a two-sample Mendelian randomization study
Chengling Liu1, Xingchen Liu2, Xin Li1
1Center of Burns and Plastic Surgery and Dermatology, The 924th Hospital of Joint Logistics Support Force of the PLA, Guilin, China.
Frontiers in Microbiology
|February 13, 2024
Summary
This study used Mendelian randomization to investigate the causal link between gut bacteria and hidradenitis suppurativa (HS). Certain gut bacteria, like Clostridium innocuum group and Lachnospira, may increase HS risk, while others, like Family XI and Porphyromonadaceae, may offer protection.
Area of Science:
- Genetics and Microbiology
- Human Health and Disease
Background:
- Alterations in gut microbiota composition are increasingly linked to hidradenitis suppurativa (HS).
- The causal relationship between gut microbiota and HS remains to be definitively established.
Purpose of the Study:
- To investigate the potential causal effects of gut microbiota on the development of hidradenitis suppurativa (HS).
- To identify specific bacterial taxa within the gut microbiome that may influence HS risk.
Main Methods:
- A bidirectional two-sample Mendelian randomization (MR) analysis was conducted.
- Genome-wide association study (GWAS) summary data for 211 gut microbial traits and HS were utilized.
- Multiple MR methods including Inverse Variance Weighted (IVW) and weighted median were applied, alongside sensitivity analyses.
Main Results:
- Four bacterial taxa demonstrated a causal association with HS: Family XI, Porphyromonadaceae, Clostridium innocuum group, and Lachnospira.
- Increased abundance of Clostridium innocuum group (OR 2.17) and Lachnospira (OR 2.45) were associated with higher HS risk.
- Conversely, increased abundance of Family XI (OR 0.67) and Porphyromonadaceae (OR 0.29) were associated with lower HS risk.
Conclusions:
- Gut microbiota composition has a direct causal impact on hidradenitis suppurativa (HS).
- Clostridium innocuum group and Lachnospira may have detrimental effects, while Family XI and Porphyromonadaceae may have protective effects on HS.
- These findings suggest potential therapeutic targets within the gut microbiome for HS management and prevention.
