Cardioprotective and hypotensive mechanistic insights of hydroethanolic extract of Cucumis melo L. kernels in...

Area of Science:

• Pharmacology
• Cardiology
• Metabolomics

Background:

• Cardiovascular diseases (CVD) pose a significant global health burden.
• Traditional medicine utilizes Cucurbitaceae seeds for various ailments, including cardiovascular issues.
• Investigating natural compounds for CVD treatment is crucial.

Purpose of the Study:

• To explore the cardioprotective and antihypertensive mechanisms of Cucumis melo (Cm) hydroethanolic seed extract (Cm-EtOH).
• To investigate the effects of Cm-EtOH on isoprenaline (ISO)-induced myocardial infarction (MI) using integrated metabolomics and computational modeling.

Main Methods:

• In vitro and in vivo models including vasoconstriction, paired atria, and blood pressure measurement.
• Metabolomics profiling to analyze biochemical and metabolite changes in ISO-induced MI rats.
• Computational cardiomyocyte simulation to assess the impact of gallic acid.

Main Results:

• Cm-EtOH exhibited vasorelaxant, negative chronotropic and inotropic effects, and hypotensive activity.
• The extract reversed ISO-induced MI-related alterations in gene expression, biochemistry, and metabolism.
• Cm- Melo seeds enhanced endothelium-derived relaxing factor (EDRF) function, energy production, and antioxidant capacity.

Conclusions:

• Cucumis melo seeds possess significant therapeutic potential for cardiovascular diseases.
• The study provides mechanistic insights into the antihypertensive and cardioprotective properties of Cm- Melo.
• Findings support the use of Cm- Melo seeds in managing myocardial and vascular disorders.