Norfloxacin penetration into human renal and prostatic tissues

Area of Science:

• Pharmacology
• Urology
• Infectious Diseases

Background:

• Norfloxacin is a fluoroquinolone antibiotic used for urinary tract infections.
• Understanding tissue penetration is crucial for optimizing antibiotic therapy.

Purpose of the Study:

• To quantify norfloxacin concentrations in human kidney and prostate tissues.
• To compare tissue norfloxacin levels with minimum inhibitory concentrations (MICs) of common pathogens.

Main Methods:

• Serum, kidney, and prostatic tissue samples were collected from 14 patients.
• Norfloxacin concentrations were determined using validated analytical methods.

Main Results:

• Mean kidney to serum norfloxacin concentration ratio was 6.6 ± 2.8.
• Mean prostate to serum norfloxacin concentration ratio was 1.7 ± 0.2.
• Achieved tissue concentrations were generally above the MICs for most urinary pathogens.

Conclusions:

• Norfloxacin demonstrates significant penetration into kidney and prostate tissues.
• These findings support the use of norfloxacin for treating infections in these sites.