Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K
Viral Structure00:56

Viral Structure

62.2K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.2K
What are Viruses?00:50

What are Viruses?

114.9K
Overview
114.9K
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

70.7K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
70.7K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.5K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.5K
Retroviruses02:33

Retroviruses

12.3K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid peroxidation impacts orthoflavivirus infection in a virus-dependent manner.

Cell death & disease·2026
Same author

Pro- and anti-viral functions of lipid droplets in infection at a glance.

Journal of cell science·2026
Same author

Glycerophospholipid remodeling is critical for orthoflavivirus infection.

Nature communications·2024
Same author

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids.

Communications biology·2024
Same author

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.

Nature microbiology·2024
Same author

Ultrastructural Features of Membranous Replication Organelles Induced by Positive-Stranded RNA Viruses.

Cells·2021

Related Experiment Video

Updated: Jul 3, 2025

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.1K

Lipid Droplets in Virus Replication.

Eva Herker1

  • 1Institute of Virology, Philipps-University Marburg, Hans-Meerwein-Strasse 2, 35043, Marburg, Germany.

FEBS Letters
|February 13, 2024
PubMed
Summary
This summary is machine-generated.

Viruses exploit host lipid droplets for energy and membrane building blocks essential for their replication. Understanding these viral strategies targeting lipid metabolism is key to developing new antiviral therapies.

Keywords:
assemblylipid dropletmetabolismreplication organellesviruses

More Related Videos

Isolation of Cellular Lipid Droplets: Two Purification Techniques Starting from Yeast Cells and Human Placentas
09:41

Isolation of Cellular Lipid Droplets: Two Purification Techniques Starting from Yeast Cells and Human Placentas

Published on: April 1, 2014

19.8K
Rapid Lipid Droplet Isolation Protocol Using a Well-established Organelle Isolation Kit
08:43

Rapid Lipid Droplet Isolation Protocol Using a Well-established Organelle Isolation Kit

Published on: April 19, 2019

11.3K

Related Experiment Videos

Last Updated: Jul 3, 2025

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.1K
Isolation of Cellular Lipid Droplets: Two Purification Techniques Starting from Yeast Cells and Human Placentas
09:41

Isolation of Cellular Lipid Droplets: Two Purification Techniques Starting from Yeast Cells and Human Placentas

Published on: April 1, 2014

19.8K
Rapid Lipid Droplet Isolation Protocol Using a Well-established Organelle Isolation Kit
08:43

Rapid Lipid Droplet Isolation Protocol Using a Well-established Organelle Isolation Kit

Published on: April 19, 2019

11.3K

Area of Science:

  • Virology
  • Cell Biology
  • Biochemistry

Background:

  • Intracellular pathogens require host metabolic processes for replication.
  • Viruses, particularly enveloped and RNA viruses, depend on host lipids for viral envelope and replication compartment formation.
  • Lipid droplets are crucial cellular energy and membrane lipid sources.

Purpose of the Study:

  • To investigate the diverse strategies viruses employ to utilize host lipid droplet biology.
  • To understand the role of lipid metabolism in viral replication.

Main Methods:

  • Analysis of viral dependence on host metabolic networks.
  • Examination of lipid requirements for viral structures and replication sites.
  • Investigation of triglyceride utilization from lipid droplets.

Main Results:

  • Viruses exploit host metabolic networks for multiplication.
  • Lipids are essential for enveloped virus envelope formation.
  • Positive-sense RNA viruses require lipids for replication compartments.
  • Viruses utilize triglycerides from lipid droplets for energy and membrane synthesis.

Conclusions:

  • Viruses have evolved sophisticated strategies to exploit lipid droplet biology.
  • Targeting viral exploitation of lipid metabolism presents a potential antiviral therapeutic avenue.