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  11. Lipid Sensing Nuclear Receptors Involved In The Pathogenesis Of Fatty Liver Disease

Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease

Marion Schweiger1,2, Maria Nieves Arredondo-Lasso1,2, Marika E Friano1,2

  • 1Metabolic Programming, TUM School of Life Sciences & ZIEL Institute for Food and Health, Gregor-Mendel-Str. 2, 85354, Freising, Germany.

FEBS Letters
|February 13, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Non-alcoholic fatty liver disease involves lipid buildup and inflammation. Nuclear receptors, such as PPARs, FXR, and LXR, are key regulators and potential drug targets for metabolic diseases.

Area of Science:

  • Hepatology and metabolic disease research.

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is characterized by progressive lipid accumulation, inflammation, and fibrosis.
  • Nuclear receptors (NRs) play a critical role in regulating metabolic pathways.

Purpose of the Study:

  • To highlight the role of specific nuclear receptors in NAFLD pathogenesis.
  • To identify NRs as potential therapeutic targets for metabolic diseases.

Main Methods:

  • Review of current literature on nuclear receptor function in liver metabolism.
  • Analysis of gene regulation by NRs through heterodimerization with Retinoid X receptor (RXR).

Main Results:

  • PPARα, PPARγ, FXR, and LXR are identified as key NRs involved in NAFLD.
  • These NRs regulate genes critical to lipid metabolism and inflammation.

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  • NRs function by forming heterodimers with RXR.

    • Conclusions:

    • Nuclear receptors represent promising targets for pharmaceutical interventions in NAFLD.
    • Targeting NRs could offer a novel therapeutic strategy for metabolic liver diseases.