Related Experiment Video
Updated: Jul 3, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Executive functions in patients with obstructive sleep apnea: exploring the prefrontal model]
J S Reyes-Silva1,2, T M Silva-Cruz2, C Colonia-Cano2
1Universidad Autónoma de México, Ciudad de México, México.
Introduction:
According to the prefrontal model, individuals with obstructive sleep apnea (OSA) manifest behaviours mimicking dysexecutive syndrome as a result of blood gas abnormalities and sleep fragmentation.
Objective:
To compare executive functions in OSA patients with normative values and explore their relationship with blood gas abnormalities and sleep fragmentation.
Patients And Methods:
Patients were recruited from the wider community and from a tertiary care hospital. The score obtained in the neuropsychological assessment was compared with Student's t-test for a sample. A multiple linear regression analysis was subsequently estimated, using polysomnographic parameters of hypercapnia, hypoxemia and sleep fragmentation as the predictor variables, and the executive function score as the variable to be predicted.
Results:
Although the neuropsychological assessment performance of 26% of this sample was classified as executive impairment, indicators of sleep fragmentation and gas abnormalities failed to predict the performance of executive functions.
Conclusion:
A proportion of the patients with OSA presented performance similar to a dysexecutive syndrome; however, the factors underlying and fostering this type of cognitive manifestation remain unclear. Early treatment for this public health problem could be the best tool available for improving quality of life and preventing health risks.
More Related Videos
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Role of Cerebellum and Prefrontal Cortex in Memory
REM Sleep Behavior Disorder
RBD is significantly associated with...
High-Level and Low-Level Awareness
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...

