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Related Experiment Video

Updated: Jul 3, 2025

Preparation of DNA-crosslinked Polyacrylamide Hydrogels
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Domain-Selective Enzymatic Cross-linking and Etching for Shape-Morphing DNA-Linked Nanoparticle Films.

Jisu Choi1, Jongwook Kim1, Jin-Young Park1

  • 1Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea.

Nano Letters
|February 13, 2024
PubMed
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Researchers developed shape-morphing DNA-linked nanoparticle films that work in diverse environments. These robust films utilize enzymatic ligation for stability and demonstrate predictable, reversible shape changes in response to stimuli.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biochemistry

Background:

  • DNA's molecular recognition enables dynamic nanostructures.
  • Conventional DNA nanostructures require strict environmental conditions for stability.

Purpose of the Study:

  • To create shape-morphing DNA-linked nanoparticle films operational across a wide range of environmental conditions.
  • To enhance the stability and responsiveness of DNA-based nanostructures.

Main Methods:

  • Site-specific enzymatic ligation of DNA.
  • DNA-based layer-by-layer thin film fabrication.
  • Domain-selective ligation and photoinduced interlayer mixing.

Main Results:

  • Fabricated nanoparticle films remained intact in challenging conditions like pure water and high temperatures.
Keywords:
DNA LigationDNA-Directed Self-assemblyGold NanoparticleLayer-by-LayerStimuli-Responsive

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  • Demonstrated predictable and reversible shape morphing in response to environmental changes and DNA exchange.
  • Created novel edge-sealed double-layered films via midlayer etching, overcoming fabrication limitations.

    • Conclusions:

    • Enzymatic ligation enhances the environmental robustness of DNA-linked nanoparticle films.
    • The developed films offer a versatile platform for stimuli-responsive nanostructures.
    • Advanced fabrication techniques enable complex film architectures with unique properties.