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Published on: December 22, 2023
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Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with
Puck J Peltenburg1,2, Lieke M van den Heuvel3,4, Dania Kallas5
1Deparment of Clinical and Exprimental Cardiology, Heart Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Summary
Non-adherence to medication and lifestyle recommendations affects 15% of catecholaminergic polymorphic ventricular tachycardia (CPVT) patients. Concerns about CPVT medication significantly increase non-adherence, highlighting the need for targeted patient education.
Area of Science:
- Cardiology
- Genetics
- Pharmacology
Background:
- Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia syndrome.
- Management involves medication and lifestyle recommendations to prevent arrhythmic events.
- Non-adherence is a significant factor in breakthrough events for CPVT patients.
Purpose of the Study:
- To investigate the incidence of non-adherence to medication and lifestyle recommendations in a large international cohort of CPVT patients.
- To identify potential reasons for non-adherence in this population.
- To explore factors associated with medication non-adherence in CPVT.
Main Methods:
- An international, multilingual online survey was distributed to CPVT patients.
- Medication adherence was assessed using the Medication Adherence Rating Scale (MARS).
- Lifestyle adherence and reasons for non-adherence were evaluated using validated questionnaires.
Main Results:
- Out of 218 participants, 200 were prescribed medication, and 15% reported non-adherence.
- Factors independently associated with non-adherence included female sex, flecainide monotherapy, and concerns about CPVT medication.
- 13.4% experienced adverse events, and 15% exceeded recommended exercise levels.
Conclusions:
- A significant rate of non-adherence exists among CPVT patients, particularly linked to medication concerns.
- Targeted patient education may improve therapy adherence in CPVT management.
- Addressing patient concerns is crucial for enhancing treatment effectiveness in CPVT.
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