Use of pattern recognition technology for determination of the human differential leukocyte count

The imprecision, inaccuracy, and clinical sensitivity of an automated differential counter based on pattern recognition technology (HEMATRAK model 590) were evaluated using the NCCLS standard H20-T. The data show that the instrument is capable of performing assays in a manner comparable with the reference method proposed by NCCLS. In addition, data are presented from a multicenter study involving 174 HEMATRAK instruments which showed that the automated systems produce results equivalent to manual procedures (based on approximately 350 individual assays).