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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Tomohisa Toda1, Tracy A Bedrosian2, Simon T Schafer3

  • 1Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Laboratory of Neural Epigenomics, Institute of Medical Physics and Micro-tissue Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany; Nuclear Architecture in Neural Plasticity and Aging Laboratory, German Center for Neurodegenerative Diseases, 01307 Dresden, Germany.

Cell Reports
|February 13, 2024
PubMed
Summary

Long interspersed nuclear elements (LINE-1) regulate brain development. These mobile genetic elements control neural differentiation rates in humans and mice, independent of their reverse transcription activity.

Keywords:
CP: Developmental biologyCP: NeuroscienceL1LINE-1brain developmentneural progenitor cellsrepetitive elements

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