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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Copper interaction with cystatin C: effects on protein structure and oligomerization

Justyna Żygowska1, Marta Orlikowska1, Igor Zhukov2

  • 1Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Poland.

The FEBS Journal
|February 13, 2024
PubMed
Summary

This study shows copper(II) ions interact with human cystatin C (hCC), primarily at histidine residues 86-90. Copper binding destabilizes hCC structure, offering insights into neurodegenerative disease mechanisms.

Keywords:
binding sitecopper ionscystatin Coligomerizationstructure

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