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Updated: Jul 3, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Different Reaction Modes Operating in ansa-Half-Sandwich Magnesium Catalysts
Leonardo I Lugo-Fuentes1, Victor A Lucas-Rosales1, J Antonio Sandoval-Mendoza1
1Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Gto, Noria Alta S/N, CP, 36050, Guanajuato, México.
Abstract:
Magnesium-based catalysts are becoming popular for hydroelementation reactions specially using p-block reagents. Based on the seminal report from Schäfer's group (ChemCatChem 2022, 14, e202201007), our study demonstrates that the reaction mechanisms exhibit a far greater degree of complexity than originally presumed. Magnesium has a variety of coordination modes (and access to different hybridizations) which allows this electron-deficient centre to modulate its catalytic power depending on the σ-donor properties of the reagent. DFT calculations demonstrate several reaction channels closely operating in these versatile catalysts. In addition, variations in limiting energy barriers resulting from catalyst modifications were examined as a function of the Hammett constant, thereby predicting enhanced efficiency in reaction conversions.
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