Related Experiment Video
Updated: Jul 3, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Natural compounds efficacy in Ophthalmic Diseases: A new twist impacting ferroptosis
Mengxia Yuan1, Qi He2, Wang Xiang3
1Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Abstract:
Ferroptosis, a distinct form of cell death, is characterized by the iron-mediated oxidation of lipids and is finely controlled by multiple cellular metabolic pathways. These pathways encompass redox balance, iron regulation, mitochondrial function, as well as amino acid, lipid, and sugar metabolism. Additionally, various disease-related signaling pathways also play a role in the regulation of ferroptosis. In recent years, with the introduction of the concept of ferroptosis and the deepening of research on its mechanism, ferroptosis is closely related to various biological conditions of eye diseases, including eye organ development, aging, immunity, and cancer. This article reviews the development of the concept of ferroptosis, the mechanism of ferroptosis, and its latest research progress in ophthalmic diseases and reviews the research on ferroptosis in ocular diseases within the framework of metabolism, active oxygen biology, and iron biology. Key regulators and mechanisms of ferroptosis in ocular diseases introduce important concepts and major open questions in the field of ferroptosis and related natural compounds. It is hoped that in future research, further breakthroughs will be made in the regulation mechanism of ferroptosis and the use of ferroptosis to promote the treatment of eye diseases. At the same time, natural compounds may be the direction of new drug development for the potential treatment of ferroptosis in the future. Open up a new way for clinical ophthalmologists to research and prevent diseases.
Insights
Ferroptosis, an iron-driven cell death, impacts eye diseases. Understanding its metabolic regulation offers new therapeutic avenues for ocular conditions.
Area of Science:
- Biochemistry
- Cell Biology
- Ophthalmology
Background:
- Ferroptosis is a regulated cell death pathway driven by iron-dependent lipid peroxidation.
- Cellular metabolism, redox balance, and iron homeostasis are key regulators of ferroptosis.
- Ferroptosis is increasingly implicated in various ocular diseases, including development, aging, immunity, and cancer.
Purpose of the Study:
- To review the concept, mechanisms, and recent advancements in ferroptosis research concerning ophthalmic diseases.
- To analyze ferroptosis in ocular diseases through the lens of metabolism, oxidative stress, and iron biology.
- To highlight key regulators, open questions, and potential therapeutic strategies involving natural compounds.
Main Methods:
- Literature review and synthesis of current research on ferroptosis and ocular diseases.
- Analysis of metabolic pathways, redox biology, and iron metabolism in the context of ferroptosis.
- Identification of key regulatory mechanisms and potential therapeutic targets.
Main Results:
- Ferroptosis is intricately linked to the pathogenesis of diverse eye conditions.
- Metabolic pathways, oxidative stress, and iron dysregulation are critical in ferroptosis-related ocular diseases.
- Natural compounds show promise as potential therapeutic agents for ferroptosis modulation in eye diseases.
Conclusions:
- Ferroptosis represents a significant area of research with implications for understanding and treating eye diseases.
- Further investigation into ferroptosis regulatory mechanisms could lead to novel therapeutic interventions.
- Natural compounds may offer a promising direction for developing new treatments for ferroptosis-associated ocular pathologies.
Related Concept Videos
01:16Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
01:27Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...