Effects of D-penicillamine on collagen biosynthesis by fibroblast cell cultures

The effects of D-penicillamine on collagen and total protein synthesis by fibroblast cell cultures were studied. High concentration of D-penicillamine (10 mmol/l) produced a toxic effect consisting of inhibition of growth and a non-specific increase in protein synthesis. A low concentration of D-penicillamine (100 mumol/l) decreased the biosynthesis of both type I and type III collagens.