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[Neurobiological basis of neonatal epilepsy and its comorbilities]

Marta Martínez-Morga1, Salvador J Martinez-Morga1, Daniel Garrigos1

  • 1Instituto de Neurociencias UMH-CSIC, Alicante, España.

Medicina
|February 13, 2024
PubMed

Insights

Neonatal seizures, often due to immature brains, can indicate neonatal epilepsy linked to brain development issues. Comorbidities significantly impact epilepsy

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Epileptology

Background:

  • Neonatal seizures are common due to brain functional immaturity.
  • Neonatal epilepsy is often associated with neurodevelopmental structural brain alterations.
  • Comorbid medical disorders affect approximately 50% of individuals with active epilepsy, altering its course.

Approach:

  • This review synthesizes current knowledge on the structural and functional brain processes involved in neonatal epilepsy.
  • It examines the relationship between epilepsy onset and preceding neurologic disorders.
  • The review explores how underlying neurobiological alterations contribute to both epilepsy and comorbidities.

Key Points:

  • Immature brain development predisposes neonates to seizures.
  • Structural brain abnormalities during neurodevelopment are linked to neonatal epilepsy.
  • Pre-existing neurologic conditions may independently predispose to epilepsy and its comorbidities.

Conclusions:

  • Understanding the neurobiological underpinnings of neonatal epilepsy and its comorbidities is crucial.
  • Identifying shared etiological factors can inform targeted interventions.
  • Further research into brain development and epilepsy is warranted.

Keywords:
TDHautismcortical dysplasianeonatal seizures

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