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Systemic Cisplatin Does Not Affect the Bone Regeneration Process in a Critical Size Defect Murine Model
Ava A Brozovich1,2,3, Stefania Lenna2,3, Carson Brenner1
1Department of Orthopedics, Ohio State University, Wexner Medical Center, 410 W. 10th Avenue, Columbus, Ohio 43210, United States.
ACS Biomaterials Science & Engineering
|February 13, 2024
Summary
This study shows that a special biomaterial (MHA/Coll) can help regenerate bone in osteosarcoma patients, even during chemotherapy treatment. This suggests current chemotherapy regimens can continue without impacting bone repair strategies.
Area of Science:
- Biomaterials Science
- Orthopedic Oncology
- Regenerative Medicine
Background:
- Osteosarcoma (OS) is a primary bone cancer requiring chemotherapy and surgery.
- Bone voids after surgery pose reconstruction challenges, potentially worsened by chemotherapy.
- Chemotherapy's impact on bone regeneration necessitates evaluating new repair materials.
Purpose of the Study:
- To assess if a magnesium-doped hydroxyapatite/collagen composite (MHA/Coll) promotes bone regeneration during chemotherapy.
- To determine if neoadjuvant or adjuvant chemotherapy affects MHA/Coll's osteogenic potential.
Main Methods:
- A critical-size bone defect model in mice was used.
- Mice received either neoadjuvant or adjuvant cisplatin chemotherapy.
- The MHA/Coll composite was implanted to facilitate bone regeneration.
Main Results:
- MHA/Coll significantly enhanced bone formation in the presence of chemotherapy.
- Bone volumes were higher with MHA/Coll and chemotherapy compared to controls.
- Statistical analysis showed positive trends for MHA/Coll's efficacy.
Conclusions:
- Neoadjuvant and adjuvant chemotherapy do not inhibit the bone regenerative capacity of MHA/Coll.
- Biomimetic scaffolds can effectively repair bone voids in OS patients undergoing chemotherapy.
- Current chemotherapy protocols may not require modification for bone repair strategies.
